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In vitro experiments further revealed that under high glucose conditions, marked increase in the expression of TRIM32 along with a concomitant downregulation in the AKT and mTOR phosphorylation levels was observed, which further exacerbated pancreatic cell autophagy and hampered insulin secretion, thereby promoting development of type 2 diabetes

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Continuation of daily l-carnitine supplementation for at least an additional month resulted in no further increase in d 3 -l-carnitined 3 -TMAO transformation in omnivores, but continued to increase d 3 -TMAO generation in vegans/vegetarians following oral d 3 -l-carnitine challenge (Figure 4A)